Journal of biochemical and molecular toxicologyCarcinomaHepatocellularLiver NeoplasmsHumansEpigenesis
FiLactate-Induced Lysine Lactylation: A Central Node Linking Metabolic Rewiring, Epigenetic Plasticity and Therapeutic Vulnerabilities in Hepatocellular Carcinoma.
Ying-Chuan Yin, Jing He, Ying Feng, Yun-Yun Xu, Xiao-Hong Shi, Xue Tan, Qiao-Juan He
Published: 202510.1002/jbt.70622
Abstract
Hepatocellular carcinoma (HCC) exploits aerobic glycolysis to generate a surplus of lactate that fuels malignant growth, immune evasion, and drug resistance. Lysine lactylation (Kla), deposited by p300/CBP using lactyl-CoA and removed by sirtuin deac…
Preview only. Read the full abstract at the source