Journal of biochemical and molecular toxicologyHumansMaleApoptosisReactive Oxygen SpeciesProstatic Neoplasms
Identification and Mechanistic Profiling of Indolin-2-One Derivatives That Induce ROS-Driven Intrinsic Apoptosis in Prostate and Colorectal Cancer Cells.
Rabin Neupane, Chandrabose Karthikeyan, Saloni Malla, Joyeeta T Khan, Charles R Ashby, Narayana Subbiah Hari Narayana Moorthy, Piyush Trivedi, Harlokesh Yadav, R Jayachandra Babu, Nageeb Hassan, Sai H S Boddu, Amit K Tiwari
Published: 202510.1002/jbt.70545
Abstract
A series of 3-(2-oxo-2-arylethylidene)indolin-2-ones were synthesized and evaluated for cytotoxic efficacy in the prostate cancer cell lines (PC-3 and DU145), and the colon cancer cell line (HCT-116), and in noncancerous Madin-Darby canine kidney (MD…
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