Journal of applied toxicology : JAT
Hepatotoxicity Mechanisms of Sirolimus and Everolimus Unveiled Through Metabolomics and Transcriptomics Analysis.
Zixin Zhang, Yingying Tang, Rongjing Xing, Wenjing Liao, Tong Qiu, Jiangyuan Zhou, Xuepeng Zhang, Xue Gong, Yuru Lan, Shanshan Xiang, Siyuan Chen, Yi Ji
Published: 202510.1002/jat.70012
Abstract
Sirolimus and everolimus, two representative inhibitors of the mammalian target of rapamycin (mTOR), have distinct therapeutic effects on numerous paediatric diseases that do not have specific treatments, particularly vascular abnormalities, but thei…
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