International journal of cancer
High potassium enhances the immunosuppressive function of myeloid-derived suppressor cells via Kir4.1-dependent metabolic reprogramming and promotes tumor immune escape.
Zhiqi Xie, Jiayi Liu, Ying Chen, Kexin Wang, Ziyi Hong, Yanjie Li, Luqiong Liang, Jinglu Bi, Yuanzhen Jin, Weida Shen, Masashi Tachibana, Zeren Shen, Jinjin Shao
Published: 202510.1002/ijc.70313
Abstract
Despite advances in cancer immunotherapy, low response rates remain a critical clinical challenge. Myeloid-derived suppressor cells (MDSCs) drive tumor immune evasion by directly suppressing antitumor immunity, positioning them as prime therapeutic t…
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