Human psychopharmacologyHumansScopolamineMaleHeart RateAdult
Scopolamine's Anticholinergic Effects on EEG Spectral, Aperiodic, Complexity, Microstates, and Heart Rate Variability.
Joseph C C Chen, Rachael L Sumner, Eric B Thorstensen, Jacqueline A Hannam, Nicholas Hoeh, Hafis Adetokunbo Ayeni, Vikrant Singh, Andrew Wilson, Douglas Campbell, Frederick Sundram, Suresh Muthukumaraswamy
Published: 202510.1002/hup.70022
Abstract
OBJECTIVE: Scopolamine disrupts cholinergic mechanisms via nonspecific muscarinic antagonism. Centrally, excitatory neocortical innervations are antagonised causing spectral electroencephalography (EEG) changes and cognitive impairment. Peripherally,…
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