Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population.

Background and Aims: Asian skin is more sensitive than Caucasian. When it comes to anti-aging treatments, some classic actives like Retinoids, are not friendly to Asian skin due to irritation issues. Therefore, it becomes more important to research new active ingredients to address the aging concern of sensitive skin. To clinically assess the anti-aging, skin soothing, barrier function improvement efficacy of one novel formulation containing supramolecular Bakuchiol and Terminalia chebula extract in Chinese sensitive skin population. Methods: A total of 34 sensitive skin subjects were enrolled in this clinical efficacy study. A routine consisting of twice daily topical applications of the test serum was followed for 28 days, evaluations were performed at baseline (D0) and after 8 h (T8h), 14 days (D14) and 28 days (D28) of using the regime. Objective skin assessment principles are skin sensitivity, barrier and aging. Sensitivity was evaluated by lactic acid sting test (LAST). Skin barrier evaluation, including transepidermal water loss (TEWL), a* value, and redness percentage. Aging evaluation, including wrinkle area, skin wrinkle (SEw), elasticity (R2), firmness (F4). As well as dermatologist evaluation of skin sensitivity and aging parameters and safety assessment. Results: TEWL, a* value, redness percentage and mean score of LAST significantly reduced by 24.90%, 10.76%, 31.81%, 28.09%, respectively, and Dermatologist assessment significant decrease in facial redness, after 28 days of skin care treatment with the test serum. Wrinkle area, SEw, F4 significantly reduced by 16.06%, 16.71%, 25.60%, respectively, and Dermatologist assessment significant decrease in facial wrinkles, while R2 significantly increased by 23.04% after 28 days. No adverse events were reported. Conclusions: The serum containing supramolecular Bakuchiol and Terminalia chebula extract achieved skin rejuvenation in sensitive skin by improving sensitive and aging skin.