Clinical Practice Guidelines for the Diagnosis of Inflammatory Bowel Disease (IBD): A Scoping Review.

Background and Aims: Inflammatory bowel disease (IBD) is a chronic autoimmune disorder. However, inconsistencies in diagnostic processes exist. This scoping review aimed to evaluate current global clinical practice guidelines (CPGs) to assist clinical decision-making. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-Scr) was utilised. CPGs were identified by searching electronic databases Medline, Scopus, Embase and grey literature until March 2024. Included guidelines were published within the last 5 years in English, with recommendations for diagnosis of IBD. Publications were independently extracted and critically appraised by two reviewers using the AGREE-II tool. Diagnostic recommendations were extracted and categorized. Results: Eleven CPGs met the inclusion criteria of this review. A total of 21 recommendations were identified and classified in relation to medical history and physical examination, blood testing, computed tomography (CT), sonography, endoscopy, colonoscopy, and magnetic resonance imaging (MRI). Conclusions: Diagnostic recommendations varied across CPGs, reflecting differences in regional practices and methodological rigor. The methodological quality was inconsistent, particularly regarding the applicability of recommendations. The findings highlight the need for harmonization of diagnostic criteria, improved guideline development processes, and further research to address gaps in clinical guidance and implementation.