GliaAnimalsMicrogliaMorphineSpinal CordWnt3A Protein
Activation of Wnt3a Signaling Rescues the Analgesic Efficacy of Morphine by Regulating Microglial Reactivation in the Spinal Cord.
Cheng Li, Hongyu Yao, Mingzheng Wu, Yiran Zhao, Bo Peng, Hong Gao, Donglin Xiong, Xue-Jun Song
Published: 202610.1002/glia.70122
Abstract
Repetitive opioid treatment promotes analgesic tolerance through mechanisms involving opioid-induced neuroinflammation. Here, we report that Wnt signaling activation can rescue opioid analgesic effects and suppress neuroinflammation by regulating mic…
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