Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead (Advanced Genetics 3/06).

Illuminating Life with Optogenetics Beams of light orchestrate cellular control: light-gated ion channels shape ion flux; photoswitchable enzymes and receptors modulate signaling pathways; light-controlled protein interactions tune function; and light-regulated gene expression. In article 202500021, Xiao Duan, Mo Zhu, and Shiqiang Gao review two decades of optogenetics, from fundamental biology to early clinical translation. The cover image is based on the article Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead by Xiao Duan et al., https://doi.org/10.1002/ggn2.202500021.