Genetic epidemiologyHumansGenotypeAlzheimer DiseaseGenome-Wide Association StudyGene Frequency
Adjustment for Genotype Imputation Uncertainty Corrects for Inflated Type I Error in Family-Based Association Testing.
Tyler R C Day, Joshua C Bis, Nicola Chapman, Alejandro Q Nato, Andrea R V R Horimoto, Harkirat Sohi, Rafael Nafikov, Elizabeth E Blue, Mohamad Saad, Ellen M Wijsman
Published: 202510.1002/gepi.70021
Abstract
Genotype imputation is a widely-used data augmentation approach that is applied to samples of related and/or unrelated individuals. Association testing may then be carried out on the complete data with commonly-used methods. This approach has typical…
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