European journal of pain (London, England)HumansFibromyalgiaChronic PainBiomarkersbeta-Endorphin
A Systematic Review With Meta-Analysis of Endogenous Opioid System Biomarkers in Patients With Chronic Axial Pain, Chronic Widespread Pain, and Fibromyalgia.
Karin Due Bruun, Maria Charlotte Reiersoel Moerkeberg, Julie Roenne Pedersen, Daniel Broholm, Morten Rune Blichfeldt-Eckhardt, Lotte Abildgren
Published: 202610.1002/ejp.70192
Abstract
BACKGROUND: The opioid system is involved in the regulation of pain as well as stress homeostasis. Stress-induced opioid dysregulation has been proposed as a mechanism for pain development in patients with fibromyalgia (FM) and chronic low back pain…
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