Drug development researchTriazolesCholinesterase InhibitorsThiazolesAcetylcholinesteraseNeurodegenerative Diseases
Novel 4-chlorophenyl and 3/4-chlorophenoxy Based Triazole/Thiazole Derivatives: Synthesis and Investigation of Their Effects on Neurodegenerative Disorders-Related Enzymes via In Vitro and In Silico.
Sam Dawbaa, Demokrat Nuha, Asaf Evrim Evren, Begüm Nurpelin Sağlik, Leyla Yurttaş
Published: 202610.1002/ddr.70219
Abstract
In this study, nine new synthesized compounds were investigated for their enzyme inhibition activity and evaluated for their ADME parameters and DFT-based properties. The compounds were classified into two main structures: derivatives of 2-(3/4-chlor…
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