Drug development researchAnti-Bacterial AgentsSulfonamidesHumansAnimalsBacterial Infections
From Sulfa Drugs to New Antibacterial Agents: Advances in Chemical Modification of Approved Sulfonamides.
Ayşe Karagüzel, Ebru Koçak Aslan, Miyase Gözde Gündüz
Published: 202510.1002/ddr.70191
Abstract
Sulfonamides, the oldest synthetic antibacterial agents, specifically target the enzyme dihydropteroate synthase (DHPS), which is essential for the folic acid biosynthesis pathway. In contrast, humans do not use this mechanism as they produce no endo…
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