Clinical and translational medicineHumansMiceAnimalsEpigenesisGenetic
DNTTIP1 drives leukaemogenesis through MiDAC-mediated epigenetic silencing of BMF.
Ruolin Xiu, Yuzhu Ma, Yueying Gao, Yao Chen, Xinyu Li, Yue Wu, Meiling Sun, Qizhao Li, Yanhong Zhao, Shuqian Xu, Shengjin Fan, Yongsheng Li, Huitao Fan
Published: 202610.1002/ctm2.70603
Abstract
BACKGROUND: Acute leukaemia is a highly aggressive malignancy with significant unmet therapeutic needs, partly due to epigenetic dysregulation. Here, we uncover deoxynucleotidyl transferase terminal-interacting protein 1 (DNTTIP1) within the mitotic…
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