Clinical and translational medicineHumansDNA MethylationSingle-Cell AnalysisChromatinHigh-Throughput Nucleotide Sequencing
High-throughput single-cell DNA methylation and chromatin accessibility co-profiling with SpliCOOL-seq.
Qingmei Shen, Enze Deng, Ling Luo, Jingna Zhang, Qifeng Yang, Dan Su, Xiaoying Fan
Published: 202610.1002/ctm2.70584
Abstract
BACKGROUND: DNA methylation and chromatin accessibility are pivotal epigenetic regulators of gene expression and cellular identity, with significant implications in tumorigenesis and progression. Current single-cell multi-omics methods are limited in…
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