Clinical and experimental dental researchHumansPyrimidinesKeratinocytesInterferon-gammaPyrazoles
Ruxolitinib Suppresses Interferon-γ-Induced JAK/STAT Activation in Oral Keratinocytes.
Kim N Stolte, Anna Fedorova, Sameh Attia, Kerstin Danker, Henrik Dommisch
Published: 202610.1002/cre2.70281
Abstract
OBJECTIVES: The Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway plays a crucial role in oral inflammatory diseases such as oral lichen planus (OLP) and periodontitis. Interferon-gamma (IFN-γ) is a cytokine that acti…
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