Current protocolsProteasome Endopeptidase ComplexProteolysisProdrugsHumansDegrons
Synthesis of Immunoproteasome N-Degron Prodrugs for Selective Protein Degradation.
Cody A Loy, Timothy J Harris, Darci J Trader
Published: 202510.1002/cpz1.70278
Abstract
Targeted protein degradation using bifunctional molecules like proteolysis targeting chimeras (PROTACs) has revolutionized drug discovery but remains limited by E3 ligase availability and lack of cell selectivity. N-degron degraders provide a smaller…
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