Clinical pharmacology and therapeutics

Lower Dose-Normalized Tacrolimus Exposure in CYP3A56 vs. 3 Loss-of-Function Allele Carriers: A Longitudinal Retrospective Real-World Study in Kidney Transplant Recipients.

Amar D Levens, Dirk Jan A R Moes, Yanick Boer, Aiko P J de Vries, Dorottya K de Vries, Danny van der Helm, Soufian Meziyerh, Dave L Roelen, Stefan Böhringer, Teun Van Gelder, Jesse J Swen

Published: 202510.1002/cpt.70162

Abstract

Pharmacogenomic research has historically focused on individuals of European ancestry, leading to the underrepresentation of genetic variants common in non-European populations. This bias is exemplified by CYP3A5*6, a functionally consequential varia…

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Lower Dose-Normalized Tacrolimus Exposure in CYP3A5*6 vs. *3 Loss-of-Function Allele Carriers: A Longitudinal Retrospective Real-World Study in Kidney Transplant Recipients.

Abstract

Lower Dose-Normalized Tacrolimus Exposure in CYP3A56 vs. 3 Loss-of-Function Allele Carriers: A Longitudinal Retrospective Real-World Study in Kidney Transplant Recipients.