Clinical pharmacology and therapeutics
Addressing Causality and Homogeneity Assumptions in Exposure-Response Analyses.
Mats O Karlsson, Divya Brundavanam
Published: 202510.1002/cpt.70132
Abstract
Exposure-response, or pharmacokinetic-pharmacodynamic (PKPD), analyses support many drug development decisions. It is typically applied without assessment of causality and homogeneity, where the latter refers to the assumption that the reason for var…
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