Comprehensive PhysiologyHumansNeoplasmsAnimalsStressPhysiological
The Integrated Stress Response in Cancer: Paradox and Therapeutic Promise.
Chenliang Zhang, Ting Zhang, Qiulin Tang, Yu Zeng, Dan Cao
Published: 202610.1002/cph4.70105
Abstract
The integrated stress response (ISR) is an evolutionarily conserved signaling pathway that converges diverse cellular stresses onto the eIF2α-ATF4 axis, thereby orchestrating a fundamental decision between adaptive survival and cell death. In cancer,…
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