Comprehensive PhysiologyAnimalsHeart FailureFemaleKidney MedullaSheep
Renal Medullary but Not Cerebral Hypoxia in a Large Animal Model of Heart Failure With Mildly Reduced Ejection Fraction.
Anton L Trask-Marino, Lachlan F Miles, Terase F Lancefield, Taku Furukawa, Lars I P Snel, Sally G Hood, Connie Pei Chen Ow, Lindsea C Booth, Jai Raman, Clive N May, Yugeesh R Lankadeva
Published: 202510.1002/cph4.70081
Abstract
BACKGROUND: Chronic kidney disease and cognitive impairment are common in heart failure, but how changes in microcirculatory perfusion and oxygenation contribute to these complications remains unclear. We investigated how heart failure with mildly re…
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