Precision Diagnosis and Individualized Therapy of Non-Gestational Choriocarcinoma Invading the Corpus Uteri and Cervix: A Case Report and Literature Review.

BACKGROUND: Non-gestational choriocarcinoma (NGCC) is a rare type of malignant tumor. Primary lesions are typically detected in the ovary and rarely invade the corpus uteri and cervix. NGCC usually has a poor prognosis due to the difficulty in achieving early and accurate diagnoses because of its rarity. CASE: This case described a female who was initially diagnosed with gestational choriocarcinoma and treated with EMA-CO chemotherapy. However, subsequent short tandem repeat (STR) analysis confirmed the diagnosis as NGCC, prompting surgical intervention. Given her favorable response and after thorough communication, three additional cycles of EMA-CO chemotherapy were recommended. At her last follow-up, her human chorionic gonadotropin level had normalized. CONCLUSION: This case presents a rare instance of NGCC with simultaneous uterine and cervical involvement, confirmed by STR analysis and successfully managed with the EMA-CO regime. It highlights the necessity of precise diagnosis and personalized treatment for effective management of this disease.