ChemMedChemLewis AcidsPotassiumIonophoresDensity Functional TheoryMolecular Structure
Lewis Acid-Initiated Cleavage of a Large Ionophore: Molecular Deactivation by Potassium Ion Binding.
Gareth Arnott, Jonah Ruskin, Antonin Knirsch, Aditya Vardhan, Adam Huczyński, Travis Dudding, Thomas Lectka
Published: 202510.1002/cmdc.202500783
Abstract
Herein, it is demonstrated that the addition of Lewis acids such as Zn(OTf)2 to a large ionophoric natural product effects a fast cleavage of the molecule into two distinct fragments. The exploration of the mechanism implicates acidification of the c…
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