ChemMedChemHeparan SulfateAntiviral AgentsPhosphatesHumansStructure-Activity Relationship
Exploring Phosphate Substitution in Heparan Sulfate Mimetics: Synthesis and Antiviral Evaluation.
Arran W Stewart, Andrew J Marshall, Sam Spijkers-Shaw, Kathy A Keith, Scott H James, Lawrence D Harris, Olga V Zubkova, Benjamin J Compton
Published: 202610.1002/cmdc.202500764
Abstract
Heparan sulfate (HS) is a ubiquitously expressed glycosaminoglycan (GAG) found on most mammalian cells. Its heterogeneous structure and dense negative charge allow HS to interact with a wide range of proteins, regulating their stability, localization…
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