ChemMedChemCarbonic Anhydrase InhibitorsMycobacterium tuberculosisPyrazolesSulfonamidesMicrobial Sensitivity Tests
Exploration of New Pyrazole-Hydrazone-Benzenesulfonamide Conjugates as Potent Mycobacterial Carbonic Anhydrase Inhibitors: Design, Synthesis, and Biological Evaluation.
Pardeep Kumar, Anuradha Singampalli, Rani Bandela, Sri Mounika Bellapukonda, Laxma Naik Korra, Ramakrishna Kodi, Subhendu Ghosh, Aman Dalal, Puja Kumari Agnivesh, Ankita Devi, Srinivas Nanduri, Nitin Pal Kalia, Niccolò Paoletti, Alessandro Bonardi, Paola Gratteri
Published: 202510.1002/cmdc.202500633
Abstract
The growing threat of multidrug-resistant tuberculosis highlights the need for new agents with alternative mechanisms of action. Herein, a series of pyrazole-sulfonamide derivatives are synthesized and evaluated for inhibition of Mycobacterium tuberc…
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