ChemMedChemHumansHistone DeacetylasesHistone Deacetylase InhibitorsProteolysisEpigenesis
PROTAC-Based HDAC Degradation: A Paradigm Shift in Targeted Epigenetic Therapies.
Ambati Himaja, Debojyoti Halder, Suvankar Banerjee, Swati Biswas, Nilanjan Adhikari, Balaram Ghosh
Published: 202510.1002/cmdc.202500203
Abstract
Proteolysis-targeting chimeras (PROTACs) have emerged as an excellent strategy for targeted protein degradation by the ubiquitin-proteasome system. Traditional inhibitors suppress the enzymatic activity, but the PROTACs utilize the method of total de…
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