Chemistry (Weinheim an der Bergstrasse, Germany)
Harnessing Toluene Solvent as a Reactant: Regioselective Benzyl Radical Addition to Multi-π 1,5-Enynes in a Copper-Catalyzed Cascade to Indenes.
Saideh Rajai-Daryasarei, Fatemeh Chahardehi, Mohammad Mahdi Sharifani, Morteza Jamshidi, Robert Stranger, Frank Rominger, Alireza Ariafard, Saeed Balalaie
Published: 202610.1002/chem.202503120
Abstract
C─H activation of toluene generates a benzyl radical that undergoes C─C coupling, converting an abundant solvent into carbon building blocks. A major challenge, however, is to direct the highly reactive benzyl radical to add regioselectively to a mul…
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