Chemistry (Weinheim an der Bergstrasse, Germany)HumansProdrugsProteolysisProteinsSmall Molecule Libraries
Bioorthogonal Chemistry: An Emerging Strategy for Targeted Protein Degradation.
Pijun Zhou, Junda Li, Jinyi Xu, Yansong Ren, Shengtao Xu
Published: 202610.1002/chem.202502876
Abstract
Targeted protein degradation (TPD) technologies represent a promising strategy to overcome drug resistance associated with traditional small-molecule inhibitors (SMIs) while targeting traditionally considered nondruggable targets. However, the freque…
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