Chemistry (Weinheim an der Bergstrasse, Germany)IndolequinonesNaphthalimidesDNACross-Linking ReagentsAmides
A Subtle Change in Linker Structure can Greatly Affect Cross-Linking Efficiency of a Quinone Methide Conjugate.
Ravina Moirangthem, Steven E Rokita
Published: 202510.1002/chem.202502288
Abstract
The generality of delivering a bisquinone methide precursor to the major groove of DNA was tested with two naphthalimide conjugates differing in a single amide versus ester linkage. Both demonstrated an ability to cross-link duplex DNA. Although a di…
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