A Rare Case of Choriocarcinoma With Myometrial Invasion Mimicking Invasive Mole: Case Report.

Gestational trophoblastic neoplasia (GTN) comprises a group of rare tumors arising from placental trophoblastic tissue, including choriocarcinoma and invasive mole. We present a rare case of choriocarcinoma with isolated myometrial invasion in a 30-year-old woman with a history of molar pregnancy and term delivery. The clinical presentation mimicked an invasive mole, with elevated β-hCG levels and imaging revealing a vascular myometrial mass. Following a failed dilation and evacuation, and in light of the patient's desire to preserve fertility, conservative surgery via laparotomy was performed. Pathology confirmed choriocarcinoma with myometrial and vascular invasion. Postoperative treatment with actinomycin-D chemotherapy led to remission, and the patient remained disease-free at two-year follow-up. This case emphasizes the importance of histopathological confirmation in GTN diagnosis and illustrates that conservative surgical management, when appropriate, can achieve both oncologic control and fertility preservation.