Chembiochem : a European journal of chemical biologyAptamersNucleotideGuanineOxidation-ReductionArginine
8-Oxo-7,8-Dihydroguanine can Improve Aptamer Affinity Toward Argininamide and its Selective Oxidation Promotes Crosslinks Formation.
Auriane Guitton-Auberty, Sandrine Perrier, Jean-Luc Ravanat
Published: 202510.1002/cbic.202500597
Abstract
The effects of the substitution of a guanine (G) base by the oxidative lesion 8-oxo-7,8-dihydroguanine (OG) on the affinity of the DNA aptamer selected against L-argininamide (L-Rm) are studied. Results indicate that, depending on the position of the…
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