Chemistry & biodiversityAnimalsMiceRAW 264.7 CellsDrug DesignPyrimidinones
Design, Synthesis, and Anti-Inflammatory Activity of Functionalized 1,2,4,5-Tetrasubstituted-Pyrimidinone.
Rayees Ahmad Naikoo, Diljeet Kumar, Nusrit Iqbal Andrabi, Yassir Arfath, Hemender Singh, Rupesh Kumar, Zabeer Ahmed, Gaurav Bhargava
Published: 202610.1002/cbdv.202502861
Abstract
A highly efficient aza-Michael addition reaction of 5-amino pyrimidinones with α, β-unsaturated olefins under optimized reaction conditions is reported. The resulting functionalized amino-pyrimidinone-based aza-Michael mono-adducts were obtained in g…
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