Synthesis of New Pyrazolo[1,5-a]Pyrazin-4(5H)-One Derivatives and Effects on PI3K Protein Levels in A549 Lung Adenocarcinoma Cell Line.

Molecular targeted therapies have significantly advanced non-small cell lung cancer (NSCLC) treatment; however, acquired resistance in advanced stages remains a critical challenge. To overcome this, novel therapeutic targets or combination strategies…

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