Chemistry & biodiversitybeta-LactamsAmidohydrolasesEnzyme InhibitorsStructure-Activity RelationshipMolecular Docking Simulation
Toward a Better Understanding of Fatty Acid Amide Hydrolase Inhibition by β-Lactams.
Axel Morelle, Juhans Dechenne, Joséphine Caruano, Olivia Vander Auwera, Gabriella Barozzino-Consiglio, Catherine Michaux, Giulio G Muccioli, Raphaël Robiette
Published: 202610.1002/cbdv.202502705
Abstract
Fatty acid amide hydrolase (FAAH) inhibition holds therapeutic promise by enhancing endocannabinoid signaling. We previously identified β-lactam compounds as reversible and selective hFAAH inhibitors with nanomolar potency. Here, we describe the synt…
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