Chemistry & biodiversityReactive Oxygen SpeciesCryptococcus neoformansAntifungal AgentsMicrobial Sensitivity TestsCell Membrane
Antifungal Activity of Polyalthic Acid Analogs Against Cryptococcus neoformans Involves Production of Reactive Oxygen Species (ROS) and Disruption of Cell Membrane Integrity.
Thomas A Mennella, Kyung U Hong, Joshua Bojito, Thomas R Roche, Eun-Jung Park, Ariana B Souza, Rodrigo C S Veneziani, Sérgio R Ambrósio, Jairo K Bastos, Suresh Annam, Cassia S Mizuno
Published: 202510.1002/cbdv.202502678
Abstract
Invasive fungal infections have a high mortality rate, and the current antifungal arsenal is limited by toxicity, resistance, and the small number of available drugs. Polyalthic acid is a natural product with modest antifungal activity and low toxici…
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