Chemistry & biodiversityPseudomonas aeruginosaQuorum SensingAmidesDrug DesignAnti-Bacterial Agents
Design, Synthesis, Biological Evaluation, and In Silico Study of N-(Pyrazin-2-yl)Alkyl/Aryl Amide Derivatives as Quorum Sensing Inhibitors Against Pseudomonas aeruginosa.
Anand Yadav, Isha Mahindru, Namita Srivastava, Rajnish Kumar, Manish Jain, Lokender Kumar, Ashok Kumar Yadav
Published: 202610.1002/cbdv.202502287
Abstract
This research develops novel quorum sensing inhibitors (QSIs) that function as anti-biofilm agents and reduce quorum sensing (QS) to effectively combat Pseudomonas aeruginosa. N-(Pyrazin-2-yl)alkyl/aryl amide derivatives (3a-k) and (5a-j) were design…
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