Chemistry & biodiversityPlasmodium falciparumAntimalarialsMolecular Docking SimulationIndole AlkaloidsStructure-Activity Relationship
Iboga-Indole Alkaloids as Potential Plasmodial Inhibitors: Identification, Biosynthesis, and Molecular Docking Studies.
Smith B Babiaka, Methodius S Lahngong, Conrad V Simoben, Dennis S B Ongarora, Godloves F Chi, Dieudonné T Tshitenge, Rajshekhar Karpoormath, Marwaan Rylands, James A Mbah, Kennedy O Abuga, E Joel Loveridge, Michel Frédérich
Published: 202510.1002/cbdv.202501035
Abstract
A previously undescribed iboga-indole alkaloid, voacamine A (1), and the known alkaloids, voacamine (2), voacorine (3), and voacangine (4) were isolated from the stem bark of Voacanga africana. The structures of the alkaloids were established by one-…
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