Biotechnology progress
Performance of large virus removal filters during AAV processing: Influence of flux and process disruptions.
Akshay S Chaubal, Asingsa W Arachchige, Annabelle J Zahn, S Ranil Wickramasinghe, Xianghong Qian, Andrew L Zydney
Published: 202610.1002/btpr.70106
Abstract
As adeno-associated viral vectors (AAV) continue to advance through the clinical pipeline, effective downstream purification strategies must be developed to ensure bulk drug purity and safety. AAV are produced within mammalian cells, bringing forth r…
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