Validated LC-MS/MS Method for Vibegron Quantification in Human Plasma via a Selective Fragment Ion (m/z 135.1): Addressing Matrix Interference and Sample Instability.

A sensitive and robust LC-MS/MS method was developed and validated for the quantification of vibegron in human plasma, employing electrospray ionization in positive mode and multiple reaction monitoring (MRM). The precursor ion m/z 445.5 yielded two…

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