Biomedical chromatography : BMCNimodipineTandem Mass SpectrometryAnimalsChromatographyHigh Pressure Liquid
Hidden Drug-Excipient Interaction by HPLC-MS/MS Analysis: Polysorbate 80 Enhances Nimodipine Systemic Exposure Through Competitive Metabolic Inhibition.
Jiameng Qu, Mingming Wang, Yinfei Ran, Junjie Yang, Yanqiao Hui, Huarong Xu, Dongsheng Zong, Qing Li
Published: 202610.1002/bmc.70330
Abstract
Pharmaceutical excipients have traditionally been regarded as pharmacologically inert carriers, serving merely as vehicles for active pharmaceutical ingredients. However, this conventional paradigm is increasingly challenged by emerging evidence reve…
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