Biomedical chromatography : BMCAnimalsTandem Mass SpectrometryMemantineRatsSprague-Dawley
Establishment of UPLC-MS/MS Method for Determining the Content of Memantine in Rat Plasma and Its Pharmacokinetic Differences at Different Altitudes.
Jinwen Wang, Chang Wang, Yingfei Zhang, Wen Yan, Jingyang Fang, Wenbin Li, Rong Wang
Published: 202610.1002/bmc.70295
Abstract
This study aimed to establish an UPLC-MS/MS method for determining memantine (MM) in rat plasma and to investigate its pharmacokinetic variations at different altitudes. MM was separated on a Hypersil Gold C18 column using a gradient elution method a…
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