Biotechnology and bioengineering
Gamma Irradiation of Poly(lactide-co-glycolide) Scaffolds Reduces the Mechanical Stability and Function of Islet Grafts in Diabetic Nonhuman Primates.
Jessica L King, Christopher Spencer, Richard Youngblood, Kelly Crumley, Elizabeth Bealer, Peter D Rios, Ira Joshi, Sofia Ghani, Douglas Isa, James J McGarrigle, David Cook, Conor Locke, Adam Abraham, Andrea Clark, José Oberholzer
Published: 202510.1002/bit.70134
Abstract
Clinical islet transplantation has long been investigated as a potential cure for type 1 diabetes (T1D), yet standard intrahepatic delivery leaves islets prone to an instant blood-mediated inflammatory response. Herein, we investigated the design of…
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