Biotechnology journalClostridiumMethylenetetrahydrofolate Reductase (NADPH2)Oxidation-ReductionMetabolic EngineeringElectrons
Modifying Methylene-Tetrahydrofolate Reductase to Disrupt Electron Bifurcation in Clostridium autoethanogenum.
Lucas W Mendelson, Alexander P Mueller, Jeremy Vasquez, Steven D Brown, R Adam Thompson
Published: 202510.1002/biot.70133
Abstract
Methylene-tetrahydrofolate reductase (MTHFR) is an important enzyme for acetogenic carbon fixation, but the redox mechanism driving this reaction is not clearly understood. Previous enzymology work and energetic accounting on species such as Clostrid…
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