British journal of clinical pharmacology
Maximal use of 0.05% topical isotretinoin in patients with congenital ichthyosis results in low systemic exposure.
Holm Schneider, Christopher G Bunick, Kathrin Hillmann, Thy N Huynh, Steven Kempers, Nicolai Peschel, Ulrike Blume-Peytavi, Joyce M C Teng, Alan M Mendelsohn, John Stinson, Lara Wine Lee
Published: 202510.1002/bcp.70423
Abstract
Congenital ichthyoses (CI) are rare, inherited skin disorders characterized by hyperkeratosis, scaling and fissuring that significantly impair patients' quality of life. Treatment options are limited, with systemic retinoids reserved for severe cases…
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