Chemistry, an Asian journal
Metal-Free Strategies for Indoles and o-Acyl Benzanilides From 2-Alkynylaniline Derivatives: Experimental and DFT Insights.
Karthick Govindan, Ravikumar Pasupuleti, Ariprasanth Ramalingam, Nian-Qi Chen, Yu-Chen Lin, Wei-Yu Lin
Published: 202610.1002/asia.202500961
Abstract
We describe a metal-free, divergent transformation of acyl-substituted 2-alkynylanilines that yields two distinct products under complementary conditions. Base-mediated intramolecular hydroamination with K2CO3 provides 2-substituted indoles, whereas…
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