Chemistry, an Asian journalCeramidesTriazolesHumansAmidesMolecular Docking Simulation
A Triazole Bioisostere-Based Approach to Understanding Ceramide Amide Bond Conformation and Function.
Seonghun Kim, Mi Jeong Kim, Jaeho Han, Jae Hyun Kim, Sang Kook Lee, Eun Hee Koh, Hyun Ju Yoo, Hyunji Lee, Sanghee Kim
Published: 202510.1002/asia.202500925
Abstract
The amide bond of ceramide can adopt either a cis or trans conformation, but the biological relevance of this geometry remains unclear. We used 1,4- and 1,5-disubstituted 1,2,3-triazoles as conformationally restricted bioisosteres to investigate the…
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