Synthesis of Promising Biguanide Derivatives Bearing Urea/Thiourea as Type II Antidiabetic Agents.

Novel biguanide hydrochloride salts were synthesized through the reaction of N-substituted-semi(thiosemi)carbazides with cyanoguanidine in an acidic medium. Antidiabetic properties of the synthesized biguanides were evaluated for their antidiabetic p…

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