Archiv der PharmazieHumansAntineoplastic AgentsCyclooxygenase 2 InhibitorsAcetaminophenStructure-Activity Relationship
Dual Anticancer and COX-2 Inhibitory Activity of Tailored Paracetamol-Alkanesulfonate Conjugates: A Promising Therapeutic Approach.
Asmaa F Kassem, Marwa M Mounier, Mostafa I Abdelglil, Sameh Abdelwahed, Ahmed A El-Rashedy, Asmaa Saleh, Mahmoud G A Saleh, Aladdin M Srour
Published: 202510.1002/ardp.70125
Abstract
Innovative paracetamol-alkanesulfonate conjugates (5a-l) were designed and synthesized through a multi-step process starting with acetaminophen. Their dual functionality as anticancer agents and inhibitors of cyclooxygenase-2 (COX-2), created through…
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