Archiv der PharmazieHumansApoptosisAntineoplastic AgentsStructure-Activity RelationshipThiazolidinediones
Harnessing Fragment Merging and Chain Extension Approaches for Designing Phthalimidoalkyl-Arylidene Thiazolidinedione Hybrids: New Frontiers in Apoptosis-Inducing Cancer Treatment.
Saad Shaaban, Ayman Abo Elmaaty, Tarek A Yousef, Marwa Sharaky, Mohamed Alaa Mohamed, Mohamed Alaasar, Arwa Omar Al Khatib, Amal F Dawood, Fatema S Alatawi, Awatif M E Omran, Khadra B Alomari, Ahmed A Al-Karmalawy
Published: 202510.1002/ardp.70118
Abstract
A series of novel phthalimidoalkyl-arylidene thiazolidinedione hybrids (10a-e and 11a-e) were designed and synthesized by the combination of the bioactive phthalimide and thiazolidinedione pharmacophores and connected via an ethyl or propyl linker. A…
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