Angewandte Chemie (International ed. in English)
Transforming RNA Degradation into Accurate RNA Detection: RNase I-Assisted Rolling Circle Amplification for Clinical Samples.
Amal Mathai, Cheng-Yu Lee, Zijie Zhang, Jimmy Gu, John D Brennan, Yingfu Li
Published: 202610.1002/anie.202525591
Abstract
Ribonucleases are powerful degradative enzymes that rapidly cleave RNA and have long been regarded as obstacles to RNA diagnostics. Detecting large, structured RNA molecules in biological samples is further complicated by extensive secondary structur…
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